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Furthermore, APOE4 directly promotes cerebral iron accumulationpositively correlated with cognitive declinethereby amplifying neurotoxicity and contributing significantly to AD incidence (200, 201)

Zoccali C, Benedetto FA, Maas R, Mallamaci F, Tripepi G, Malatino LS, Bger R (2002) Asymmetric dimethylarginine, C-reactive protein, and carotid intima-media thickness in end-stage renal disease