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Role of cytochrome P450S in the generation and metabolism of reactive oxygen species

66 Both intramuscular and oral vitamin B12 therapy have been reported to be associated with an acneiform eruption that appeared within one week to five months after initiation of treatment and was characterized by papules and pustules on the face, neck, shoulders, chest, and upper portion of back

doi: 10.1038/ijo.2015.178

GLP-1 receptor agonism reduces appetite, slows gastric emptying, increases glucose-dependent insulin secretion, and suppresses glucagon

Rhoads et al., 1997)

These not only eliminated the possibility that phospholipid changes were an off-target effect of the chemical- and/or genetic manipulations, but also provided independent models of mitochondrial hyperpolarization, including in the context of a disease