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For instance, HK2, the first rate-limiting enzyme in glycolysis, localizes to the nucleus, where it interacts with chromatin-associated factors such as 53BP1 and RAD51, potentially influencing the DDR [145]

A deficiency may lead to a wide range of symptoms, including: Ongoing fatigue or low energy Brain fog or difficulty concentrating Low mood or irritability Pale skin or a yellow tinge Tingling or numbness in the hands and feet Shortness of breath Dizziness or feeling faint Mouth ulcers or sore tongue Blurred vision Some of these symptoms may also be caused by iron deficiency

Treatment led to downregulation of IGF-1R and phosphorylated Akt, which in turn decreased the Bcl-2/Bax ratio at both the protein and mRNA levels

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Detection was performed using a variable wavelength detector adjusted to 280 nm, at 20C and 38% rH

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