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In the absence of substrates, and with bound ADP, the catalytic cleft is in the open conformation, and the GLUD1 hexamers form long polymers in the crystal cell with more interactions than found in the abortive complex crystals (8AR8 [9] )

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Regulatory T cells in tumor microenvironment: new mechanisms, potential therapeutic strategies and future prospects

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Sekula P, Dunant A, Mockenhaupt M, Naldi L, Bouwes Bavinck JN, Halevy S, et al