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As for TGR5, it has been reported to the activation of TGR5 could reduce the area of atherosclerotic plaques, reduce inflammation in plaques, and inhibit phagocytosis of oxLDL by macrophages [368, 369]

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Phenyl-substituted isoindolinone ligands for PROTACs construction In 2023, Tang and colleagues reported a library of C4-phenyl lenalidomide derivatives resulting from the direct attachment of ortho-, meta- and para-substituted phenyl groups via an optimized Suzuki cross-coupling reaction (Scheme 14) 129