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Although these models are instrumental for mechanistic studies, they fail to fully recapitulate the multifactorial and long-term nature of human ovarian aging, which is shaped by decades of environmental exposures, metabolic comorbidities, genetic heterogeneity, and chronic inflamm-aging settings (Wang et al., 2025

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doi: 10.3389/fmicb.2025.1685962 Received 28 August 2025 Accepted 27 October 2025 Published 12 November 2025 Volume 16 - 2025 Edited by Vikash Kumar, Central Inland Fisheries Research Institute (ICAR), India Reviewed by Sijie Wang, Affiliated Hospital of Guangdong Medical College Hospital, China Xuchang Zhou, The First Affiliated Hospital of Xiamen University, China Updates Copyright 2025 Wang, Xu, Zha and Wu

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