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Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) signaling in angiogenesis: a crucial target for anti- and pro-angiogenic therapies

For example, a ferritin-based vaccine which self-assembles the SARS-CoV-2 WA-1 spike glycoprotein with a unilamellar liposomal adjuvant containing monophosphoryl lipid A and saponin QS-21 (ALFQ) elicited robust antibody responses in a Phase 1, first-in-human trial (Ober Shepherd et al

doi:10.1016/bs.ircmb.2015.07.007 pmid:26614873 Szargel R, Shani V, Elghani FA, Mekies LN, Liani E, Rott R, Engelender S (2016) The PINK1, synphilin-1 and SIAH-1 complex constitutes a novel mitophagy pathway

(2012) 7:e34693

The treatment involves a 300 mg/kg dose, administered in three separate doses over 21 hours

Course in the hospital and outcome The diagnosis of acute severe hemolysis with methemoglobinemia was made