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Trials investigating melanotan 1 as an implant in skin disorders like erythropoietic protoporphyria (EPP) have applied the peptide as a 16mg implant every 60 days (8mg/month), for up to 6 implants a year (e.g

It is usually discussed around MC1R-associated signalling, pigmentation pathway models, receptor selectivity, and peptide analogue stability

Clinicians should be aware of possible oral mucosal hyperpigmentation in patients taking imatinib mesylate

Russell SM

Oral melanocytic pigmentations have been reported in patients with Laugier-Hunziker syndrome (idiopathic lenticular muco-cutaneous pigmentations) and with Carney complex (spotty skin pigmentations, myxomas and endocrine overactivity)

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