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Metformin, the first-line treatment recommended by NICE for type 2 diabetes, interferes with vitamin B12 absorption in the gut through a calcium-dependent mechanism

DOI: [69] J

While findings remain preliminary, they highlight important pathways such as angiogenesis, cellular migration, and inflammatory regulation

and v) with the CDAA diet with rifaximin and L-carnitine, as previously described (23,24)

Moreover, PD patients had higher serum IGF-1 expression, with a significant correlation between IGF-1 levels and cognitive function scores as well (Ma et al., 2015)

For the remainder of this section, we will focus on parvalbumin chandelier cells since these are the interneurons known to play a major role in prefrontal cortexdependent working memory and also have been implicated in the pathophysiology of neuropsychiatric disorders such as schizophrenia [60, 62]