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Polyphenols exert their effects by targeting multiple pathways implicated in PD, including neuroinflammation, oxidative stress (reactive oxygen species, ROS), and protein aggregation, thereby potentially protecting vulnerable neurons (12) (Figure 1)

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Rather, recent evidence suggests that H 2 S exists in dynamic equilibrium with supersulfides in biological systems, leading to challenges in isolating the pure effects of H 2 S

Invest Ophthalmol Vis Sci 58(8):20292029 Maldonado E, Morales-Pison S, Urbina F, Solari A (2023) Aging Hallmarks and the Role of Oxidative Stress

Kidney tissue slices of Fh1 fl/fl Cre-negative control mice and Cre-positive mice in which Fh1 was lost (indicated hereafter as Fh1 / ) were subjected to the same protein extraction and cysteine labelling strategies as cells, and peptide oxidation ratios were normalised for protein abundance