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2 Metabolic reprogramming in AML 2.1 Changes in oxidative phosphorylation Most AML cells have mutations in one or more genes that affect cell growth or metabolic function and anomalies in mitochondrial metabolism are frequently observed (3, 4, 3437)

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Increases of the antioxidant molecules glutathione and NADPH and the NO precursors arginine and citrulline were seen, as well as the expected increases in RBC ATP and 2,3-DPG (Gehrke et al., 2019)

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[DOI] [PubMed] [Google Scholar] 11.James LP, Mayeux PR, Hinson JA