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Description

Mechanism of certain drugs induced ototoxicity The following sections detail the ototoxicity of key drug classes, including anti-cancer agents, aminoglycoside antibiotics, cytostatic drugs, diuretics, and antimalarial medications (Fig

STAM Model In the STAM model, a single dose (200 g) of the pancreatic -cell toxin STZ is administered subcutaneously to 2 day old neonatal C57BL/6 mice followed by 46 weeks of HFD feeding (Fujii et al., 2013

[ 1 ] Once this unstable, highly reactive molecule encounters a stable molecule, it will steal off its electrons and continue doing so, damaging them in the process