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doi: 10.1016/S0264-410X(00)00257-7 242 MurphyJR

It carries four substitutions, notably D-Ala at position 2, studied in vitro for increased resistance to dipeptidyl-peptidase-IV (DPP-IV) cleavage

proposed an indirect anticancer effect of venetoclax with the aid of dendritic cells (DCs) in vivo, depicted as the imgration and antigen presentation capacity of conventional type-1 DCs being potentiated by the activation of the cGAS/STING pathway and the subsequent classical type-1 interferon pathway when BCL2 is genetically or pharmacollogically inhibited, which eventually improves the immunosurveillance capacity of T cells and enhances ICI therapeutic efficacy