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Description

Cell 157 , 15771590 (2014)

I know you'll be successful!" Dr

elegans 5 has emerged as a highly effective system for whole-organism high-throughput genetic 6,7,8,9,10,11,12,13,14 and drug 15,16,17,18,19 screening

Mitochondria affect ferroptosis at the level of the cytosolic iron pool regulation by fine-tuning the iron influx from the cytosol into mitochondria, at the level of electron transport chain by adjusting mitROS generation and oxidative phosphorylation via AMPK activation in the energy-deficient state, and at the level of tricarboxylic acid (TCA) cycle affecting the content of NADPH and GSH [162, 166]