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CMA involves the identification of KFERQ-like motifs present in the cytosolic proteins by heat shock cognate 71 kDa protein cytosolic (Hsc70c), a chaperone protein, followed by the direction to the lysosomal membrane receptor lysosomal-associated membrane protein 2A and the translocation of cargo proteins to the lysosomal lumen (5)

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A scaffold protein inhibitor of protein kinase cascades phosphatidylethanolamine-binding protein 1 (PEBP1) complexes with 15-LOX isoforms, 15LO-1, and 15LO-2, and the number of co-localized PEBP1/15LO-1 puncta in the freshly brushed airway epithelial cells have a strong correlation with increased FeNO in type 2 asthma patients, implying the potential role of ferroptosis in asthma [96]

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[Google Scholar] 59.Zhang S, et al

Among the emerging mediators, exerkines, physical exercise-induced signaling molecules, are secreted by multiple tissues, including the skeletal muscle, bone, liver, and adipose tissue, and mediate the systemic beneficial impacts of exercise via autocrine, paracrine, and endocrine signaling