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10.14288/hfjc.v14i2.305 15 DongH.LinZ

In the years following the introduction of iodine in the salt and addition to bread, there were publications of an increase in the number of cases of (temporary) thyrotoxicosis immediately after the start of the iodine supplement in areas where there was a long-term deficiency of iodine and a high incidence of goitre (5)

Figure 3 An R2R3-MYB transcription factor has been identified as a master regulator (29)

Oncotarget 8, 81649

Studies have highlighted the role of persistent fibrosis in aged tissues, where myofibroblasts in injured tissues of aged mice acquire a sustained senescent and apoptosis-resistant phenotype, exacerbating fibrosis (Hecker et al., 2014)