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The literature mentions that a complete reduction in expression decreases resistance to a variety of zraP inducing antimicrobials, such as the DNA- targeting fluoroquinolone lomefloxacin, as well as compounds that target replication and protein synthesis (Rome et al., 2018)

According to numerous retrospective case-controlled studies, moderate increases in plasma homocysteine, which can be precisely quantitated by high performance liquid chromatography (HPLC), raise the risk for cardiovascular disease 2-fold, after adjusting for classic risk factors

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In one embodiment, a targeting peptide tethered to an iRNA agent and/or the carrier oligomer can be an amphipathic -helical peptide

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