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Patterson, M

Atchaneeyasakul LO, Linck LM, Connor WE, Weleber RG, Steiner RD

Clinical efficacy and safety of dotinurad, a novel selective urate reabsorption inhibitor, in Japanese hyperuricemic patients with or without gout: randomized, multicenter, double-blind, placebo-controlled, parallel-group, confirmatory phase 2 study

NASH can lead to fibrosis, and scarring of the liver, and may progress to cirrhosis or liver cancer if left untreated

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FIGURE 3 Furthermore, a thorough mutagenesis study of Md ACO1, identified other important residues essential for ACO activity: C28, T157, K158, R175, Q188, K199, K230, R244, S246, K292, E294, E297, R299, F300, and E301 (Zhang et al., 2004