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In plants, Cu/Zn-SOD is predominantly in chloroplasts, cytoplasm, and peroxidase, while Mn-SOD and Fe-SOD are predominantly in mitochondria and chloroplasts, respectively (Du et al., 2001)

Mitochondrial dysfunction plays a crucial role in the development of HPH

Additionally, its crucial to note that some antioxidant supplements have been investigated for their possible advantages in lowering oxidative stress, while the data for their efficiency is conflicting and should be reviewed with a healthcare provider (48)

19 Two additional scales used to evaluate opiate withdrawal in adults are the 16-item Subjective Opiate Withdrawal Scale (SOWS) 20 and the 10-item Short Opioid Withdrawal ScaleGossop (SOWS-Gossop)