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agalactiae [6] is one of the two (other being Listeria monocytogenes [5]) organisms first reported to synthesize GSH by a multidomain bifunctional fusion protein (GshF or GshAB) in which the N-terminal domain is responsible for -glutamylcysteine synthetase activity and the C-terminal domain carries glutathione synthetase activity

Biphalin acetate shows analgesic effect in acute, neuropathic, and chronic animal pain models

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doi: 10.1126/sciadv.adi5501 144 FangCZhongRLuSYuGLiuZYanCet al

Conclusion There is little convincing evidence in favor of glutathione as a therapy for hyperpigmentation at the present time, and there are many unresolved controversies that surround its use (Figure 5)