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Increased sleep latency, poor sleep quality and reduced latency to first rapid eye movement sleep are well documented in MDD, but there is no data supporting the role of circadian rhythm genes in the disorder (Thase, 2006)

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The positive rate of P16 gene methylation is significantly higher in lymph node metastasis of GC Considered the second largest tumor suppressor gene after TP53 , the P16 gene belongs to the INK4 gene family

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