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Bull Environ Contam Toxicol 69:885891 Qi XZ, Xue MY, Yang SB, Zha SB, Wang GX, Ling F (2017) Ammonia exposure alters the expression of immune-related and antioxidant enzymes-related genes and the gut microbial community of crucian carp ( Carassius auratus )

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Cynaroside not only blocks the interaction between ligands (pathogen-associated molecular patterns, PAMPs) and their receptor (pattern recognition receptors, PRRs), but also inhibits the activation of downstream signaling nuclear factor kappa-B (NF-B), NLRP3 and janus kinase/signal transducer and activator of transcription (JAK/STAT) inflammatory pathways (Surh et al., 2001

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