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Van HMJ, Zhang Y, Thijssen V, Buijs N, Gao Y, Mateuszuk L, Fedak FA, Kij A, Campagna R, Sartini D (2021) Macrocyclic peptides as allosteric inhibitors of nicotinamide N -methyltransferase (NNMT)

Additionally, use of bacteriostatic water is contraindicated in any patient with a known hypersensitivity to benzyl alcohol, as it could provoke an allergic reaction in such individuals

No validated human dose, half-life or safety programme was identified

It is the positively charged 5-amino-1-methylquinolinium component supplied with iodide as its counterion

While large human trials are pending, preclinical and mechanistic evidence is strong