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PMID: 165 BoodaghidizajiMJunglesTChenTZhangBYaoTLandayAet al

Meanwhile, toxicity studies have suggested that paeoniflorin has low acute toxicity, minimal subacute and chronic toxicity, and no genotoxic or mutational toxic effects

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5.2.2 Limitations due to the disease The pathophysiology of mutations or mechanisms underlying the neuronal pathology of mitochondrial diseases is still unknown in most patients, which makes it difficult to interpret the mitochondrial or neural readout in pharmacological screenings

and finally employs an endosomal enzyme, cathepsin L (CTSL) for fusogenic release of its viral genome

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