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Structural studies further demonstrated that KL001 binds to the FAD-binding pocket of CRY and interferes with its recognition by FBXL3, thus hindering CRY ubiquitination and the consequent proteasomal degradation 144

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Biochemical and biophysical research communications , 280 (1), 132138.

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For pharmacological treatments, animals with palpable tumors were randomized to receive daily intraperitoneal injection of AOA (1.1 mg/kg in PBS), syrosingopine (5.5 mg/kg in corn oil), or solvent control

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In numerous animal MASLD models, a decrease in GST specific activity was observed (Hanafi et al

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