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A hallmark feature of this resistance is its reversible nature, with drug sensitivity recoverable through genetic or pharmacological targeting of resistance-associated regulatory factors

Interestingly, the presence of functional microglia in brain slices [53] or in human cortical organoids attenuated the A-mediated induction of ferroptosis [50]

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Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer

Gratifyingly, this frustrated state in these warheads allowed the development of cysteine targeting drugs with (a) higher selectivity compared to open-chain (acyclic) covalent inhibitors with an acrylamide warhead and (b) prominent GSH tolerance

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