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RNA silencing of the mitochondrial ABCB7 transporter in HeLa cells causes an iron-deficient phenotype with mitochondrial iron overload

In particular, FLNA mutations cause periventricular nodular heterotopia, a brain malformation due to abnormal neuronal migration, in which a subset of neurons fails to migrate into the developing cerebral cortex (73) or a wide spectrum of congenital malformations, such as otopalotodigital syndrome, frontometaphyseal dysplasia, and Melnick Needles syndrome (74)