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reported that homozygous mutations in SLC39A14 cause systemic Mn accumulation, directly implicating this protein in Mn transport 52

Those numbers tell only part of the story

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Lett Drug Des Discovery 16(10):11671174 Laun AS et al

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Although these studies strongly suggest that rooibos and its polyphenols effect their antidiabetic potential through multiple modes of action, some authors have suggested that because rooibos and/or aspalathin are capable of scavenging intracellular reactive oxygen species (ROS), the anti-diabetic potential of rooibos may be due to its antioxidative function, which may be involved in the activation of insulin-stimulated glucose uptake, and hence the modulation of glucose homeostasis [257]