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5 Ubiquitin pathways and their impact on health and disease 5.1 Disruption of circadian rhythms and UPS in human health Disruptions in the circadian clock and UPS have been increasingly implicated in several disease states, particularly where proteostasis and time-dependent biological processes intersect

Participants also needed to be over 18 years of age, fluent in English, and have a habitual bedtime before midnight determined by a 7-day assessment with sleep diaries and actigraphy (Actiwatch-2, Actiwatch Spectrum

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For cell and animal assays, IBM SPSS Statistics for Windows (IBM Corp.) was used

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