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[DOI] [PubMed] [Google Scholar] 42.Cooper A.J.L., Jeitner T.M

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Similarly as in human AMD, the agedependent AMDlike pathologies in VEGFA hyper mice were associated with progressive attenuation of visual function with diminished electroretinogram (ERG) amplitudes and reduced rhodopsin levels, providing further evidence for the clinicopathologic relevance of these morphologic observations for human AMD (Ablonczy et al , 2014)

While the causal relationship between free radicals and aging, as it was originally described, has been contradicted by more recent animal studies 2,3 , the complex association between mitochondria and aging has been consolidated and further explored 4