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They are involved in reactive oxygen species (such as superoxide anions, hydrogen peroxide, and hydroxyl radicals) and lipid peroxidation product (such as malondialdehyde, 4-hydroxynonenal, F2-isoprostane, leukotriene) detoxification generated during mitochondrial respiration

Glutamate excitotoxicity Anticancer drugs and some antibiotics elevate glutamate levels in the synaptic cleft between inner hair cells (IHCs) and auditory neurons, leading to overstimulation of N-methyl-D-aspartate (NMDA) receptors

[14] The risk of liver injury is influenced by several factors including the dose ingested, concurrent alcohol or other drug intake, interval between ingestion and antidote, etc

Pooled In Vitro and In Vivo CRISPR-Cas9 Screening Identifies Tumor Suppressors in Human Colon Organoids

Numerous studies have hence been carried out investigating the interaction between PI3K or mTOR inhibitors and cisplatin, which in fact have displayed a synergistic anti-tumor effect in chemo-naive or resistant cancers, e.g

S2a-b), consistent with a reduction in cell proliferation