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Ohara T

Trends Biochem Sci 22: 211216

10.1016/B978-0-443-18486-4.00017-8 292

For example, S1PR1 can utilize Rho kinase and PI3K-Akt1 signaling to modulate peritoneal macrophage migration, whereas S1PR2 can stimulate cAMP production by activating NLRP3 inflammasomes but inhibiting AKT phosphorylation, and thus inhibit macrophage migration [141]