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Maintenance / Long-Term Research Protocol Amount: 200300mcg Frequency: 35 days weekly Duration: Variable depending on research design Research Notes Lower-frequency protocols are sometimes investigated in maintenance-focused research protocols

10.1128/mbio.02249-14 205

Mira Meeus, Jo Nijs, Linda Hermans, Dorien Goubert & Patrick Calders (2013) The role of mitochondrial dysfunctions due to oxidative and nitrosative stress in the chronic pain or chronic fatigue syndromes and fibromyalgia patients: peripheral and central mechanisms as therapeutic targets?, Expert Opinion on Therapeutic Targets, 17:9, 1081-1089, DOI: 10.1517/14728222.2013.818657 Myhill S, Booth NE, McLaren-Howard J

GenBank accession No

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Once activated, AMPK suppresses anabolic processes such as lipid and protein synthesis, while enhancing catabolic pathways, including FAO and autophagy, to restore energy homeostasis