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Eur J Immunol (2021) 51:241729

These phenomena can ultimately lead to a vicious cycle that promotes the development of inflammation and further damage to the barrier

other times, its acute

In addition, both MSCs and HGF stimulated the development of neurons and the proliferation and migration of myelinating oligodendrocytes (OLs), reduced pro-inflammatory cytokines, and enhanced anti-inflammatory cytokines

The first one is structural neuroplasticity which refers to synaptic plasticity, it is a change in the strength between neurons (synapses), chemical or electric meeting points between brain cells