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Despite these efforts, research has demonstrated the PNE in any form has the potential to result in deleterious outcomes such as placental abruption, preterm birth, low birth weight and fetal growth restriction, stillbirth, and sudden infant death syndrome [ In conclusion, the results of this review suggest the importance of ceasing smoking and any form of nicotine exposure during pregnancy to mitigate the risk of long-lasting complications on offspring

Figure 2 shows the incidence of metabolic syndrome according to HTP use during up to 24 months of follow-up

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