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Most of the reports currently described show that resistant leukemic cells have enhanced mitochondrial activity, while other works suggest that impaired or stable mitochondrial activity could be related to resistance

This region-specific action is associated with its local stimulation of hormone-sensitive lipase and enhanced fatty acid oxidation, suggesting potential for site-selective metabolic modulation without systemic hormonal changes

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The alanine substitution does not abolish copper binding but does modify the geometry, the binding affinity, and the biological characterization of the complex

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