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Animal experiments (in mice) have shown that pharmacologic blockade or genetic deletion of the Y1- and Y5-receptors reduces food intake and weight, with Y1-receptor signaling appearing to be the major mediator of the orexigenic effects of NPY

[PubMed: 15001546] 138

One question you might be asking is, Will semaglutide make me sick? While some patients do experience side effects like nausea or digestive discomfort, many find these symptoms manageable with medical guidance