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Several tests can help guide treatment upon initial presentation of sickle-cell related pain, including a CBC, blood chemistry profile, folate and vitamin B12 status, thyroid function tests, urine analysis, and chest x-ray (Mousa 2010)

4 Challenges and perspectives of ferroptosis in kidney diseases Ferroptosis, an iron-dependent regulated cell death driven by lipid peroxidation, has emerged as a central pathogenic mediator in kidney diseasesan organ uniquely susceptible to redox imbalance due to its high metabolic activity, abundant iron handling, and structural heterogeneity (276, 277)

Journal of the Chinese Medical Association

Superoxide anion (O 2 ) is an important ROS and is formed by several enzymatic and non-enzymatic pathways (Figure 2)

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