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Methods Ethics statement All animal-based experiments were performed using the protocol (M005916-R01-A01) approved by the Animal Use and Care Committee of the University of WisconsinMadison and consistent with the standards of the National Institutes of Health

Front Immunol 13:1037255 Masson P, Kelly PJ, Craig JC, Lindley RI, Webster AC (2015) Risk of stroke in patients with ESRD

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Dihexa's plasma half-life of 24 hours means twice-daily dosing provides more consistent c-Met receptor activation throughout the day, though total daily dose remains the same