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An experimental study of Valerian extract combating myocardial ischemia reperfusion injury

Zhang W, Liu Y, Liao Y, Zhu C, Zou Z

Despite the close functional interdependence of the nervous and vascular systems, the exact mechanisms by which neurovascular dysfunction leads to neurodegeneration remain to be fully elucidated (6)

ChemSusChem 9, 29122916

Glutathione levels also decrease naturally as a result of aging

In accordance with the glutathione activator hypothesis, only positively charged amino acids replace Lys105 in enzymatically active glutaredoxins, whereas in inactive isoforms and other members of the thioredoxin superfamily the activator candidate is often separated from the catalytic cysteine residue in the primary sequence or is replaced by uncharged residues 3,11,12 (Fig