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Supplementary Data 2 (download XLSX DESeq data from RNA analysis

The overwhelming dominance of ROS generated by enzymes like NADPH oxidases and xanthine oxidase over antioxidants like superoxide dismutase causes cell injury and tissue damage through direct injury, lipid peroxidation and protein oxidation leading to protease release and antioxidant and antiprotease enzyme inactivation as well as alteration of transcription factors activator protein-1 and NFB

In another work, OVA-challenged mice not treated with APO exhibited substantial increases in plasma cytokine concentration, particularly TNF and IL-4 and IL-6

Speiser, Daniel E

Diet and lifestyle changes (to reduce stress), along with certain supplements can be effective in bringing cortisol levels down

Leukemia 13(11):1881-92, 1999