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Insulin-like growth factor I and growth hormone (GH) treatment in GH-deficient humans: differential effects on protein, glucose, lipid, and calcium metabolism

Since we confirmed the expression of CRYAB-HIS protein (figure 2.15), we used a commercial kit (Capturem His-tagged Purification Miniprep Kit from Clontech) to test purification using CRYAB and CRYAB-HIS

Like the Glu-scan on the shorter MP-081 peptide, introduction of Glu residues generally decreased cellular activity, this included the A12E substitution (MP-834), which contrasts with what we observed with the shorter peptide

The main distinction is their size

Research Applications This selective activity makes AOD9604 an attractive candidate for obesity treatment and body composition optimization research, as it theoretically provides the metabolic benefits of growth hormone for fat reduction without the growth-promoting effects that could stimulate cancer cell proliferation, cause acromegaly-like symptoms, or induce insulin resistance