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SKU: 47407046189
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found that nicotine can mediate the pyroptosis of aortic endothelial cells and exacerbate the formation of atherosclerotic plaques by constructing an ApoE-/- mouse atherosclerosis model (93)

While not listed as a direct adverse effect in FDA prescribing information, this cold sensitivity appears linked to the medication's weight loss effects rather than direct temperature regulation changes