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A 2015 Australian survey on levels of crucial nutrients, including vitamin B12, found many had suboptimal levels

The upregulated CD38 was also observed during the aging process, by secreted cytokines IL-6, interferons and soluble factors from senescent cells as part of so-called senescence-associated secretory phenotype (SASP) 21,27,36,47,48,49,50

[1] AOD9604: an anti-obesity drug with some insulin-like effects Heffernan M, et al

Vitamin B12 plays a vital role in: Red blood cell production Nervous system function DNA synthesis Energy metabolism What are the symptoms of vitamin B12 deficiency