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Acta Paediatr Scand, 72: 411-414

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AOD-9604 offers a distinct, IGF-1-independent lipolysis mechanism worth studying in its own right

In bulk tumor cells, the IGF1R-induced activation of PI3K-Akt signaling results in radio-resistance by inhibiting cell apoptosis and promoting cell survival (Robbins et al., 1992

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