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Phosphomimetic substitution (S/T D/E) of these sites reduced TDP-43 phase separation and aggregation in vitro and in cells, endowing the TDP-43 condensate with more dynamic and liquid-like properties 90

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insoluble lipid or protein deposits accumulating between Bruchs membrane and RPE

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GCGR: the negative control Glucagon is on the chart only to be ruled out