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Energy stress-mediated AMPK activation and the activation of the Nrf2 antioxidant pathway also play important roles in regulating ferroptosis, through which metformin could alleviate ferroptosis and vascular calcification in high-lipid model mice

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The impact of aged garlic extract on adriamycin-induced testicular changes in adult male Wistar rats

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Macrophage inflammatory pathways are also activated leading to increased oxidative stress and enhanced cytokine/chemokine secretion, causing more LDL/remnant oxidation, endothelial cell activation, monocyte recruitment, and foam cell formation (Figure 1)

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doi: 10.1016/j.nut.2018.05.020 12

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M., Tong, Z., Paul, C

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