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Curr Neurovasc Res 10:247255 Starke RM, Thompson JW, Ali MS, Pascale CL, Martinez LA, Ding D, Chalouhi N, Hasan DM, Jabbour P, Owens GK et al (2018) Cigarette smoke initiates oxidative stress-induced cellular phenotypic modulation leading to cerebral aneurysm pathogenesis