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For example, Echinacea purpurea has been shown to support immune health in dogs, though it is not the Association of Animal Feed and Control Officials (AAFCO)-defined ingredient

Less than 3% of the administered dose is excreted in the urine as the unchanged drug, and renal clearance constitutes no more than 1%2% of the administered dose over a 24-h period

But and its a big but under certain fairly common circumstances, production can start to sputter

(PubMed) Lynch DR, Fischbeck KH

In contrast, a direct activity against phospholipids has been described for a PlpD homologue from Fusobacterium nucleatum (Trunk et al., 2019)