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Cells were then washed three times with serum-free culture medium or an appropriate solution to thoroughly remove extracellular DCFH-DA

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At the place of oxidative injury, the expression of pro-inflammatory cytokines IL-1, IL-6, TNF-, and MIP-1a is increased

In a randomized, double-blind, placebo-controlled trial, daily supplementation with Lactobacillus plantarum ECGC 13110402 for 12 weeks in adults with moderate hypercholesterolemia resulted in a significant reduction in LDL cholesterol and hs-CRP compared to placebo, suggesting a direct benefit of probiotics on cardiovascular risk markers in humans (Costabile et al., 2017)

Most users see improvements in 24 weeks when combined with regular activity